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AS/400 Total Cost of Ownership (TCO): Real Numbers, Case Studies & Cost Drivers

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What Is AS/400 Total Cost of Ownership (TCO)? AS/400 Total Cost of Ownership (TCO) refers to the complete long-term cost of running and maintaining an IBM i system, including hardware, software, licensing, staffing, maintenance, energy, upgrades, and operational overhead.  AS/400 System Savings: Why the Old Workhorse Still Wins on Cost In 2026, many enterprises are re-evaluating legacy infrastructure costs. Surprisingly, when analyzed properly, AS/400 systems often deliver lower long-term TCO compared to cloud-only or full migration strategies. Understanding the real numbers behind AS/400 TCO is critical for CIOs and CFOs making modernization decisions. Why TCO Matters More Than Initial Cost Many organizations focus only on upfront expenses, such as: Hardware refresh Migration project cost Licensing fees However, TCO includes ongoing costs over 5–10 years. A low initial migration cost may lead to: Higher recurring cloud subscriptions Increased data transfer c...
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An Introduction to Data Normalization in Bioinformatics Workflows

 Intent and Scope This article introduces the concept of data normalization in bioinformatics workflows. It is intended for educational purposes only and does not provide medical, regulatory, or analytical guidance. 1. What Is Data Normalization? Data normalization is the process of adjusting values in a dataset to reduce technical variation while preserving meaningful biological signals. In bioinformatics, normalization is commonly applied to high-throughput data such as gene expression, sequencing counts, and other molecular measurements. Without normalization, comparisons across samples or experimental conditions can be misleading due to differences in data scale or measurement bias. 2. Why Normalization Is Essential in Bioinformatics Bioinformatics datasets often combine data generated under varying conditions, platforms, or protocols. These inconsistencies can introduce technical noise that obscures true biological patterns. Normalization helps: Improve comparability...
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Unlocking Business Value from Retired Applications with Solix

  Introduction: Retired Does Not Mean Useless When applications are retired, their data often remains valuable for analytics, reporting, and strategic decision-making. However, traditional archiving approaches make this data difficult to access. Solix Application Retirement Solution preserves data usability while eliminating the cost of legacy systems. Enterprise Business Records (EBRs) Solix organizes archived data into Enterprise Business Records, preserving relationships, context, and metadata. This ensures that historical data remains meaningful and usable long after the application is retired. Self-Service Data Access Business users can search, query, and retrieve archived data without relying on IT teams. This self-service model improves productivity and accelerates decision-making. Analytics and BI Integration Solix enables integration with BI and analytics tools, allowing organizations to analyze historical trends, support forecasting, and train AI models. Retired d...
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Why Solix Is the Foundation for Scalable, Compliant, and Cost-Efficient Enterprise Data Management

 Enterprises today are under constant pressure to manage explosive data growth while enabling AI innovation and meeting strict regulatory requirements. Traditional data platforms struggle to balance scalability, governance, and cost control. Disk/Object Storage in the AI-Ready Data Era   Solix addresses these challenges by providing a unified, enterprise-grade data management platform designed for long-term scalability and compliance. The Challenge of Enterprise Data Sprawl Most organizations face: Rapid growth of structured and unstructured data Legacy systems that are expensive to maintain Siloed data environments across cloud and on-prem platforms Increasing compliance and audit demands Without a unified strategy, data sprawl leads to higher costs, security risks, and slower innovation. Solix: One Platform for the Entire Data Lifecycle Solix manages enterprise data from creation to retirement through an integrated, policy-driven platform. By centralizing...
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7 Ways Enterprise AI Is Unlocking Speed, Accuracy, Compliance, and Innovation in Clinical Trials

  Unlocking speed, accuracy, compliance, and innovation in the clinical trial value chain through Enterprise AI solutions Clinical trials are becoming increasingly complex, data-intensive, and regulated. Life sciences organizations must manage massive volumes of structured and unstructured data while maintaining strict compliance and accelerating timelines. In this environment, unlocking speed, accuracy, compliance, and innovation in the clinical trial value chain through Enterprise AI solutions is no longer a competitive advantage—it is a necessity. Enterprise AI enables organizations to modernize clinical trials by embedding intelligence, automation, and governance across the entire value chain. Below are seven powerful ways Enterprise AI is transforming clinical trials . 1. Accelerating Patient Identification and Recruitment Patient recruitment remains one of the biggest causes of clinical trial delays. Manual eligibility screening and fragmented data sources slow down enro...
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Data Governance Roles and Responsibilities Matrix: A Practical Guide for Modern Enterprises

 As enterprises generate, store, and consume unprecedented volumes of data, data governance has become a business-critical discipline. information governance platform Yet many organizations struggle not because of technology gaps, but because of unclear ownership and accountability . This is where a data governance roles and responsibilities matrix becomes essential. A well-defined matrix clarifies who owns data, who manages it, who protects it, and who ensures compliance —turning governance from theory into execution. In this guide, we break down: What a data governance roles and responsibilities matrix is Why it matters for large enterprises Key governance roles and responsibilities A practical matrix you can adapt Best practices for implementation How enterprise platforms like Solix enable governance at scale What Is a Data Governance Roles and Responsibilities Matrix? A data governance roles and responsibilities matrix is a structured framework—oft...
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How to Build a Scalable Framework for FDA 21 CFR Part 11 and GxP Compliance

  As life sciences companies expand their digital ecosystems, the pressure to maintain FDA 21 CFR Part 11 and GxP Compliance continues to rise. The regulatory landscape is no longer limited to simple document control and audit trails. Today, organizations must manage massive data flows from cloud systems, electronic records, AI-driven workflows, automated labs, and global clinical operations. Without a scalable compliance framework, even small gaps can lead to audit failures, fines, product delays, or reputational damage. This article explains how enterprises can build a future-ready, scalable, and technology-driven compliance foundation designed for modern data complexity. Why Scalability Matters in FDA 21 CFR Part 11 and GxP Compliance Traditional compliance systems were built to manage structured records inside isolated applications. But today’s environment includes: Distributed cloud platforms AI/ML pipelines Cross-site manufacturing Global supply chains Hybr...
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